Selected Publications

Yang, J., Jin, Z. B., Chen, J., Huang, X. F., Li, X. M., Liang, Y. B., Mao, J. Y., Chen, X., Zheng, Z. L., Bakshi, A., Zheng, D. D., Zheng, M. Q., Wray, N.R., Visscher, P.M., Lu, F., and Qu, J. (2017). “Genetic signatures of high-altitude adaptation in Tibetans.” PNAS, 114:4189-4194.

Zhu, Z.H., Zhang, F., Hu, H., Bakshi, A., Robinson, M. R., Powell, J. E., Montgomery, G. W., Goddard, M. E., Wray, N.R., Visscher, P.M., and Yang, J. (2016). “Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets.” Nat Genet, 48:481-487.

Okbay A, Beauchamp JP, Fontana MA, Lee JJ, Pers TH, Rietveld CA, Turley P, Chen GB, Emilsson V, Meddens SF, Oskarsson S, Pickrell JK, Thom K, Timshel P, de Vlaming R, Abdellaoui A, Ahluwalia TS, Bacelis J, Baumbach C, Bjornsdottir G, Brandsma JH, Pina Concas M, Derringer J, Furlotte NA, Galesloot TE, Girotto G, Gupta R, Hall LM, Harris SE, Hofer E, Horikoshi M, Huffman JE, Kaasik K, Kalafati IP, Karlsson R, Kong A, Lahti J, van der Lee SJ, deLeeuw C, Lind PA, Lindgren KO, Liu T, Mangino M, Marten J, Mihailov E, Miller MB, van der Most PJ, Oldmeadow C, Payton A, Pervjakova N, Peyrot WJ, Qian Y, Raitakari O, Rueedi R, Salvi E, Schmidt B, Schraut KE, Shi J, Smith AV, Poot RA, St Pourcain B, Teumer A, Thorleifsson G, Verweij N, Vuckovic D, Wellmann J, Westra HJ, Yang J, Zhao W, Zhu, Z.H., Alizadeh BZ, Amin N, Bakshi A, Baumeister SE, Biino G, Bønnelykke K, Boyle PA, Campbell H, Cappuccio FP, Davies G, De Neve JE, Deloukas P, Demuth I, Ding J, Eibich P, Eisele L, Eklund N, Evans DM, Faul JD, Feitosa MF, Forstner AJ, Gandin I, Gunnarsson B, Halldórsson BV, Harris TB, Heath AC, Hocking LJ, Holliday EG, Homuth G, Horan MA, Hottenga JJ, de Jager PL, Joshi PK, Jugessur A, Kaakinen MA, Kähönen M, Kanoni S, Keltigangas-Järvinen L, Kiemeney LA, Kolcic I, Koskinen S, Kraja AT, Kroh M, Kutalik Z, Latvala A, Launer LJ, Lebreton MP, Levinson DF, Lichtenstein P, Lichtner P, Liewald DC,; LifeLines Cohort Study, Loukola A, Madden PA, Mägi R, Mäki-Opas T, Marioni RE, Marques-Vidal P, Meddens GA, McMahon G, Meisinger C, Meitinger T, Milaneschi Y, Milani L, Montgomery GW, Myhre R, Nelson CP, Nyholt DR, Ollier WE, Palotie A, Paternoster L, Pedersen NL, Petrovic KE, Porteous DJ, Räikkönen K, Ring SM, Robino A, Rostapshova O, Rudan I, Rustichini A, Salomaa V, Sanders AR, Sarin AP, Schmidt H, Scott RJ, Smith BH, Smith JA, Staessen JA, Steinhagen-Thiessen E, Strauch K, Terracciano A, Tobin MD, Ulivi S, Vaccargiu S, Quaye L, van Rooij FJ, Venturini C, Vinkhuyzen, A.A., Völker U, Völzke H, Vonk JM, Vozzi D, Waage J, Ware EB, Willemsen G, Attia JR, Bennett DA, Berger K, Bertram L, Bisgaard H, Boomsma DI, Borecki IB, Bültmann U, Chabris CF, Cucca F, Cusi D, Deary IJ, Dedoussis GV, van Duijn CM, Eriksson JG, Franke B, Franke L, Gasparini P, Gejman PV, Gieger C, Grabe HJ, Gratten, J., Groenen PJ, Gudnason V, van der Harst P, Hayward C, Hinds DA, Hoffmann W, Hyppönen E, Iacono WG, Jacobsson B, Järvelin MR, Jöckel KH, Kaprio J, Kardia SL, Lehtimäki T, Lehrer SF, Magnusson PK, Martin NG, McGue M, Metspalu A, Pendleton N, Penninx BW, Perola M, Pirastu N, Pirastu M, Polasek O, Posthuma D, Power C, Province MA, Samani NJ, Schlessinger D, Schmidt R, Sørensen TI, Spector TD, Stefansson K, Thorsteinsdottir U, Thurik AR, Timpson NJ, Tiemeier H, Tung JY, Uitterlinden AG, Vitart V, Vollenweider P, Weir DR, Wilson JF, Wright AF, Conley DC, Krueger RF, Davey Smith G, Hofman A, Laibson DI, Medland SE, Meyer MN, Yang, J., Johannesson M, Visscher, P.M., Esko T, Koellinger PD, Cesarini D, Benjamin DJ.,(2016). “Genome-wide association study identifies 74 loci associated with educational attainment.” Nature, 533:539-542.

Marioni, R. E., Harris, S. E., Shah, S., McRae, A. F., von Zglinicki, T., Martin-Ruiz, C., Wray, N.R., Visscher, P.M., and Deary, I. J. (2016). “The epigenetic clock and telomere length are independently associated with chronological age and mortality.” Int J Epidemiol, 45:424-432.

Gratten, J., Wray, N.R., Peyrot, W. J., McGrath, J. J., Visscher, P.M., and Goddard, M. E. (2016). “Risk of psychiatric illness from advanced paternal age is not predominantly from de novo mutations.” Nat Genet, 48:718-724.

Zhu, Z.H., Bakshi, A., Vinkhuyzen, A.A.E, Hemani, G., Lee, S. H., Nolte, I. M., van Vliet-Ostaptchouk, J. V., Snieder, H., Esko, T., Milani, L., Magi, R., Metspalu, A., Hill, W. G., Weir, B. S., Goddard, M. E., Visscher, P.M., Yang, J., and LifeLines Cohort, S. (2015). “Dominance Genetic Variation Contributes Little to the Missing Heritability for Human Complex Traits.” Am J Hum Genet, 96:377-385.

Yang, J., Bakshi, A., Zhu, Z.H., Hemani, G., Vinkhuyzen, A.A.E, Lee, S. H., Robinson, M. R., Perry, J. R. B., Nolte, I. M., van Vliet-Ostaptchouk, J. V., Snieder, H., Esko, T., Milani, L., Magi, R., Metspalu, A., Hamsten, A., Magnusson, P. K. E., Pedersen, N. L., Ingelsson, E., Soranzo, N., Keller, M. C., Wray, N.R., Goddard, M. E., Visscher, P.M., and LifeLines Cohort, S. (2015). “Genetic variance estimation with imputed variants finds negligible missing heritability for human height and body mass index.” Nat Genet 47:1114-1120.

Moser, G., Lee, S. H., Hayes, B. J., Goddard, M. E., Wray, N.R., and Visscher, P.M. (2015). “Simultaneous discovery, estimation and prediction analysis of Complex Traits using a bayesian Mixture Model.” Plos Genetics, 11:22.

Marioni, R. E., Shah, S., McRae, A. F., Chen, B. H., Colicino, E., Harris, S. E., Gibson, J., Henders, A. K., Redmond, P., Cox, S. R., Pattie, A., Corley, J., Murphy, L., Martin, N. G., Montgomery, G. W., Feinberg, A. P., Fallin, M. D., Multhaup, M. L., Jaffe, A. E., Joehanes, R., Schwartz, J., Just, A. C., Lunetta, K. L., Murabito, J. M., Starr, J. M., Horvath, S., Baccarelli, A. A., Levy, D., Visscher, P.M., Wray, N.R., and Deary, I. J. (2015). “DNA methylation age of blood predicts all-cause mortality in later life.” Genome Biol, 16:2.

Lee, S. H., Byrne, E.M., Hultman, C. M., Kahler, A., Vinkhuyzen, A.A.E, Ripke, S., Andreassen, O. A., Frisell, T., Gusev, A., Hu, X. L., Karlsson, R., Mantzioris, V. X., McGrath, J. J., Mehta, D., Stahl, E. A., Zhao, Q. Y., Kendler, K. S., Sullivan, P. F., Price, A. L., O’Donovan, M., Okada, Y., Mowry, B. J., Raychaudhuri, S., Wray, N.R., and Schizophrenia Working Grp, P. (2015). “New data and an old puzzle: the negative association between schizophrenia and rheumatoid arthritis.” Int J Epidemiol, 44:1706-1721.

Yang, J., Zaitlen, N. A., Goddard, M. E., Visscher, P.M., and Price, A. L. (2014). “Advantages and pitfalls in the application of mixed-model association methods.” Nat Genet, 46:100-106.

Witte, J. S., Visscher, P.M., and Wray, N.R. (2014). “The contribution of genetic variants to disease depends on the ruler.” Nat Rev Genet, 15:765-776.

Gratten, J., Wray, N.R., Keller, M. C., and Visscher, P.M. (2014). “Large-scale genomics unveils the genetic architecture of psychiatric disorders.” Nat Neurosci, 17:782-790.

Wray, N.R., Yang, J., Hayes, B. J., Price, A. L., Goddard, M. E., and Visscher, P.M. (2013). “Pitfalls of predicting complex traits from SNPs.” Nat Rev Genet, 14:507-515.

Lee, S. H., Ripke, S., Neale, B. M., Faraone, S. V., Purcell, S. M., Perlis, R. H., Mowry, B. J., Thapar, A., Goddard, M. E., Witte, J. S., Absher, D., Agartz, I., Akil, H., Amin, F., Andreassen, O. A., Anjorin, A., Anney, R., Anttila, V., Arking, D. E., Asherson, P., Azevedo, M. H., Backlund, L., Badner, J. A., Bailey, A. J., Banaschewski, T., Barchas, J. D., Barnes, M. R., Barrett, T. B., Bass, N., Battaglia, A., Bauer, M., Bayes, M., Bellivier, F., Bergen, S. E., Berrettini, W., Betancur, C., Bettecken, T., Biederman, J., Binder, E. B., Black, D. W., Blackwood, D. H. R., Bloss, C. S., Boehnke, M., Boomsma, D. I., Breen, G., Breuer, R., Bruggeman, R., Cormican, P., Buccola, N. G., Buitelaar, J. K., Bunney, W. E., Buxbaum, J. D., Byerley, W. F., Byrne, E.M., Caesar, S., Cahn, W., Cantor, R. M., Casas, M., Chakravarti, A., Chambert, K., Choudhury, K., Cichon, S., Cloninger, C. R., Collier, D. A., Cook, E. H., Coon, H., Cormand, B., Corvin, A., Coryell, W. H., Craig, D. W., Craig, I. W., Crosbie, J., Cuccaro, M. L., Curtis, D., Czamara, D., Datta, S., Dawson, G., Day, R., De Geus, E. J., Degenhardt, F., Djurovic, S., Donohoe, G. J., Doyle, A. E., Duan, J. B., Dudbridge, F., Duketis, E., Ebstein, R. P., Edenberg, H. J., Elia, J., Ennis, S., Etain, B., Fanous, A., Farmer, A. E., Ferrier, I. N., Flickinger, M., Fombonne, E., Foroud, T., Frank, J., Franke, B., Fraser, C., et al. (2013). “Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs.” Nat Genet, 45:984-994.

Gratten, J., Visscher, P.M., Mowry, B. J., and Wray, N.R. (2013). “Interpreting the role of de novo protein-coding mutations in neuropsychiatric disease.” Nature Genetics, 45:234-238.

Yang, J., Loos, R. J. F., Powell, J. E., Medland, S. E., Speliotes, E. K., Chasman, D. I., Rose, L. M., Thorleifsson, G., Steinthorsdottir, V., Maegi, R., Waite, L., Smith, A. V., Yerges-Armstrong, L. M., Monda, K. L., Hadley, D., Mahajan, A., Li, G., Kapur, K., Vitart, V., Huffman, J. E., Wang, S. R., Palmer, C., Esko, T., Fischer, K., Zhao, J. H., Demirkan, A., Isaacs, A., Feitosa, M. F., Luan, J., Heard-Costa, N. L., White, C., Jackson, A. U., Preuss, M., Ziegler, A., Eriksson, J., Kutalik, Z., Frau, F., Nolte, I. M., Van Vliet-Ostaptchouk, J. V., Hottenga, J. J., Jacobs, K. B., Verweij, N., Goel, A., Medina-Gomez, C., Estrada, K., Bragg-Gresham, J. L., Sanna, S., Sidore, C., Tyrer, J., Teumer, A., Prokopenko, I., Mangino, M., Lindgren, C. M., Assimes, T. L., Shuldiner, A. R., Hui, J., Beilby, J. P., McArdle, W. L., Hall, P., Haritunians, T., Zgaga, L., Kolcic, I., Polasek, O., Zemunik, T., Oostra, B. A., Junttila, M. J., Groenberg, H., Schreiber, S., Peters, A., Hicks, A. A., Stephens, J., Foad, N. S., Laitinen, J., Pouta, A., Kaakinen, M., Willemsen, G., Vink, J. M., Wild, S. H., Navis, G., Asselbergs, F. W., Homuth, G., John, U., Iribarren, C., Harris, T., Launer, L., Gudnason, V., O’Connell, J. R., Boerwinkle, E., Cadby, G., Palmer, L. J., James, A. L., Musk, A. W., Ingelsson, E., Psaty, B. M., Beckmann, J. S., Waeber, G., Vollenweider, P., Hayward, C., Wright, A. F., Rudan, I., et al. (2012). “FTO genotype is associated with phenotypic variability of body mass index.” Nature, 490:267-272.

Yang, J., Ferreira, T., Morris, A. P., Medland, S. E., Madden, P. A. F., Heath, A. C., Martin, N. G., Montgomery, G. W., Weedon, M. N., Loos, R. J., Frayling, T. M., McCarthy, M. I., Hirschhorn, J. N., Goddard, M. E., Visscher, P.M., Genetic Invest, A. T., and Meta-A, D. I. G. R. (2012). “Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits.” Nat Genet, 44:369-U170.

Wray, N.R., Lee, S. H., and Kendler, K. S. (2012). “Impact of diagnostic misclassification on estimation of genetic correlations using genome-wide genotypes.” Eur J Hum Genet, 20:668-674.

Visscher, P.M., Brown, M. A., McCarthy, M. I., and Yang, J. (2012). “Five Years of GWAS Discovery.” American Journal of Human Genetics, 90:7-24.

Lee, S. H., DeCandia, T. R., Ripke, S., Yang, J., Sullivan, P. F., Goddard, M. E., Keller, M. C., Visscher, P.M., Wray, N.R., Schizophrenia Psychiat, G.-W., Int Schizophrenia Consortium, I. S. C., and Mol Genetics, S. (2012). “Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs.” Nature Genetics, 44:247-U35.

Lee, S. H., DeCandia, T. R., Ripke, S., Yang, J., Sullivan, P. F., Goddard, M. E., Keller, M. C., Visscher, P.M., Wray, N.R., Schizophrenia Psychiat, G.-W., Int Schizophrenia Consortium, I. S. C., and Mol Genetics, S. (2012). “Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs.” Nat Genet, 44:247-U35.

Deary, I. J., Yang, J., Davies, G., Harris, S. E., Tenesa, A., Liewald, D., Luciano, M., Lopez, L. M., Gow, A. J., Corley, J., Redmond, P., Fox, H. C., Rowe, S. J., Haggarty, P., McNeill, G., Goddard, M. E., Porteous, D. J., Whalley, L. J., Starr, J. M., and Visscher, P.M. (2012). “Genetic contributions to stability and change in intelligence from childhood to old age.” Nature, 482:212-215.

Yang, J., Lee, S. H., Goddard, M. E., and Visscher, P.M. (2011). “GCTA: A Tool for Genome-wide Complex Trait Analysis.” Am J Hum Genet, 88:76-82.

Yang, J., Manolio, T. A., Pasquale, L. R., Boerwinkle, E., Caporaso, N., Cunningham, J. M., de Andrade, M., Feenstra, B., Feingold, E., Hayes, M. G., Hill, W. G., Landi, M. T., Alonso, A., Lettre, G., Lin, P., Ling, H., Lowe, W., Mathias, R. A., Melbye, M., Pugh, E., Cornelis, M. C., Weir, B. S., Goddard, M. E., and Visscher, P.M. (2011). “Genome partitioning of genetic variation for complex traits using common SNPs.” Nat Genet, 43:519-U44.

Wray, N.R., Purcell, S. M., and Visscher, P.M. (2011). “Synthetic associations created by rare variants do not explain most GWAS results.” Plos Biology, 9:11.

Lee, S. H., Wray, N.R., Goddard, M. E., and Visscher, P.M. (2011). “Estimating Missing Heritability for Disease from Genome-wide Association Studies.” Am J Hum Genet, 88:294-305.

Yang, J., Benyamin, B., McEvoy, B. P., Gordon, S., Henders, A. K., Nyholt, D. R., Madden, P. A., Heath, A. C., Martin, N. G., Montgomery, G. W., Goddard, M. E., and Visscher, P.M. (2010). “Common SNPs explain a large proportion of the heritability for human height.” Nat Genet, 42:565-U131.

Powell, J. E., Visscher, P.M., and Goddard, M. E. (2010). “Reconciling the analysis of IBD and IBS in complex trait studies.” Nat Rev Genet, 11:800-805.