Annique Claringbould

Visiting Academic

During the visit, I will be doing research on the application of Mendelian Randomisation methodologies to genetic expression data. Specifically, the results of a large-scale meta-analysis study ascertaining effects of genetic risk factors on gene expression t hat we recently completed will be evaluated using this method. To better understand the effect of common genetic variation on disease risk, the goal of the project is to obtain insight into the chain of dysregulation in the cell. Through Mendelian Randomisation I will study whether a risk factor influences epigenetic methylation and in turn gene expression, or the other way around, and whether this process differs for several common diseases